VANILLA ( vanillin ) POWER

You would never think of this as a healant but it has some unusual properties as well in regard to being a muscle relaxant for those spazing muscles or aches we acquire in life—have a look and enjoy

Vanilla Benefits

 

Some things Vanilla is Effective for in Health— An actual medicinal use of vanillin for the limited purpose of treating of sickle cell anemia, a blood disorder, has been reported by D. Abraham, et al., “Vanillin, a Potential Agent for the Treatment of Sickle Cell Anemia,” Blood, Vol. 77, No. 6 (March 15) 1991: pp. 1334-1341—-

 

ðVanilla– ( vanillin) relates to the psychotherapeutic use for the natural product vanillin and derivatives of vanillin. This psychotherapeutic use of vanillin encompasses its use as an anti-anxiety agent, an anticonvulsant, and/or as a sedative (sleeping drug).—It has been found that vanillin can be used as a short term, psychotherapeutic agent in mammalian recipients–In one aspect, the vanillin is administered by injection at a dose of at least about 200 mg/kg body weight of a rodent host, preferably a dose in the range of about 200 to about 1,500 mg/kg. The optimal dose for humans ranges from about 2.0 to about 3.0 mg/kg body weight[U1] . When so administered, vanillin has been discovered to exhibit properties characteristic of CNS depressants in mammalian subjects. These uncovered attributes of vanillin show it to be suitable for use in treatment of anxiety and anxiety disorders, such attributes including short term muscle relaxation and impairment, suppression of small motor movements without affecting gross motor movements in the host, enhancement of the duration of barbituate-induced loss of righting reflex, and anticonvulsant activity. The vanillin molecule is devoid of nitrogen, and it represents a relatively safe, non-toxic tranquilizing agent—It has been found that vanillin mimics the effects of conventional tranquilizers such as those of the benzodiazepine family, in that it relaxes the large skeletal muscles and has a direct effect on the brain. In doing so, vanillin has been found to relax the host and make the host more tranquil, or sleepier (e.g., if used as an adjunct with a sleep-inducing barbituate such as pentobarbital). The vanillin is especially effective for short term duration after administration in these psychotherapeutic uses while being extremely safe and without causing the adverse side effects often associated with many conventional tranquilizers—-

ðVanillin Has Muscle relaxing effect as well - The signs were distinctly observed with appreciable frequency at the highest dose administered of 200 mg/kg. Some of the rats were rendered temporarily unable to walk, although the ability to walk returned within less than 10 minutes. However, a larger number of animals did not initiate ambulation, but could and did move about if prodded. The most prevalent and most persistent effect of vanillin was on grip strength, which was weakened in most rats by the intermediate dose of vanillin and was obliterated by the highest dose. This effect was noticeably diminished within 10 minutes, but some slight effect persisted for 45 minutes or more following the highest dose.— The result suggests a muscle relaxing effect induced by the vanillin

 

ðActive ingredient in Vanilla

Vanillin has the chemical name 4-hydroxy-3-methoxybenzaldehyde and the chemical structure: ##STR1## Vanillin occurs naturally in vanilla beans, potato parings, and Siam benzoin, and is produced synthetically from eugenol or guaiacol or from the lignin waste from the wood pulp industry

ðVanillin is relatively nontoxic; the Merck index reports an oral LD 50 for vanillin of 1580 mg/kg in rats. The relative safety of vanillin is further borne out by the fact that it was given GRAS (i.e., “generally regarded as safe”) status by the Flavor and Extract Manufacturer’s Association (FEMA) and was recognized for food use by the Food and Drug Administration (FDA). In humans, vanillin is converted to vanillic acid in the liver and is excreted in the urine

 

Commercial Drugs For Sedation– These benzodiazepines are generally effective for relief of symptoms of anxiety, tension, fatigue or agitation and present a low risk of lethality in humans when taken alone (e.g., diazepam has an oral LD 50 of 1240 mg/kg in rats). They nonetheless can have serious adverse side effects. For instance, known reported side effects of these benzodiazepines include the fact that they can be abused if taken for extended periods of time; also withdrawal symptoms can occur upon discontinuance of the therapy; they are subject to certain drug interaction concerns; and they may cause birth defects in first trimester fetuses, and/or make the fetus dependent upon the drug, and they can even be transmitted from a medicated mother to newborn infants through breast milk.

This is what you do not want to use

As for vanilla—the active ingredient in it is vanillin—according to this research the vanillin itself could be used to induce relaxation and rest –to make this just take the dosage levels from a vanilla ( the dose with be either 66 -99 drops ) –

In All ventures a suggested dose does not imply a safe dose –so always start out with less 10-20 drops ( you can always add more if needed )and add to water 2-3 oz before bed—would not suggest to take this if operating machinery or needed to be alert

 

Recipes For Relaxing and Sleeping—take 10 drops of vanilla and add to water and use 3-5 drops of lavender tincture—Consume this before bed

Other suggestions

Take 5-10 drops of vanilla and take it with gaba 500mgs

Take5-10 drops of vanilla with 500mgs of glycine

Take 5-10 drops of vanilla with 500mgs of taurine

Take 10 drops of vanilla with 5 drops of valerian root tincture

Combine 5-10 drops of vanilla with 200mgs of magnesium

Take 5-10 drops with of vanilla with motherwort 5 drops

Take 5-10 drops with of vanilla with 5 drops of passion flower

Combo any of these  such as glycine and magnesium and add 5 drops of vanilla

Combine  5-10- drops with niacinamide 250-500 mgs

These should have a relaxing impact as well to reduce the inflammatory issues of the days work load as well

Or take alone add 10 drops in water or brandy or wine mix well and drink– you may want to go up or diminsh this will depend on the impact it has with you and your reaction—if minimal then go up 1-2 drops til reaching dose—if to much and you feel overwhelmed then drop of 2-3 drops again til you see the right fit

 

The data summarized suggest that vanillin possesses some mild anticonvulsant activity, particularly at higher doses. The 300 mg/kg dose of vanillin did appear to afford some protection versus Metrazol-induced seizures—this dose is high– again take the same equivalent of a 150lb person convert to Kilos and you get 330kgs X 300mg and you are in the ball bark or 9900 miligrams or 9.9grams

 

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Evaluation of antioxidant activity of vanillin by using multiple antioxidant assays

Abstract

BACKGROUND: Vanillin, a compound widely used in foods, beverages, cosmetics and drugs, has been reported to exhibit multifunctional effects such as antimutagenic, antiangiogenetic, anti-colitis, anti-sickling, and antianalgesic effects. However, results of studies on the antioxidant activity of vanillin are not consistent.

METHODS: We systematically evaluated the antioxidant activity of vanillin using multiple assay systems. DPPH radical-, galvinoxyl radical-, and ABTS(+)-scavenging assays, ORAC assay and an oxidative hemolysis inhibition assay (OxHLIA) were used for determining the antioxidant activity.

RESULTS AND CONCLUSION: Vanillin showed stronger activity than did ascorbic acid and Trolox in the ABTS(+)-scavenging assay but showed no activity in the DPPH radical- and galvinoxyl radical-scavenging assays. Vanillin showed much stronger antioxidant activity than did ascorbic acid and Trolox in the ORAC assay and OxHLIA. In the ABTS(+)-scavenging assay, ORAC assay and OxHLIA, vanillin reacted with radicals via a self-dimerization mechanism. The dimerization contributed to the high reaction stoichiometry against ABTS(+) and AAPH-derived radicals to result in the strong effect of vanillin. Oral administration of vanillin to mice increased the vanillin concentration and the antioxidant activity in plasma. These data suggested that antioxidant activity of vanillin might be more beneficial than has been thought for daily health care.

GENERAL SIGNIFICANCE: Based on the results of the present study, we propose the addition of antioxidant capacity to the multifunctionality of vanillin.

Copyright © 2010 Elsevier B.V. All rights reserved.

 

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Vanillin enhances TRAIL-induced apoptosis in cancer cells through inhibition of NF-kappaB activation.

Lirdprapamongkol K, Sakurai H, Suzuki S, Koizumi K, Prangsaengtong O, Viriyaroj A, Ruchirawat S, Svasti J, Saiki I.

Laboratory of Biochemistry, Chulabhorn Research Institute, Bangkok 10210, Thailand.

Abstract

BACKGROUND: Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) is a promising anticancer agent which selectively kills cancer cells with little effect on normal cells. However, TRAIL resistance is widely found in cancer cells. We have previously reported antimetatstatic and antiangiogenic effects of vanillin, a flavoring agent from vanilla. Here we have evaluated the sensitizing effect of vanillin on a TRAIL-resistant human cervical cancer cell line, HeLa.

MATERIALS AND METHODS: Cell viability after treatments was determined by the WST-1 cell counting kit. Apoptosis was demonstrated by detection of caspase-3 activation and cleavage of poly (ADP-ribose) polymerase using immunoblot analysis. Effect of treatments on TRAIL signaling pathway and nuclear factor kappaB (FN-kappaB) activation was studied using immunoblot analysis and luciferase reporter assay.

RESULTS: Pretreatment of HeLa cells with vanillin enhanced TRAIL-induced cell death through the apoptosis pathway. Vanillin pretreatment inhibited TRAIL-induced phosphorylation of p65 and transcriptional activity of NF-kappaB.

CONCLUSION: Vanillin sensitizes HeLa cells to TRAIL-induced apoptosis by inhibiting NF-kappaB activation.

PMID: 20668316 [PubMed – indexed for MEDLINE

 

 

 



 [U1]Take 2.2 and multiply by body weight in pounds and then multiply that number by either 2 or 3 and you will get a dose ratio-example would be a 150 lb person X 2.2 = 330 X2 = 660 mgs or 330 X3 = 990 mgs so if you were using a dropper to extract this then you would either use 66 drops or 99 drops