Tony Pantalleresco Radio Show script of the Week November-22-2010

Show of the Week November-22-2010


Food additives and hyperactive behaviour in 3-year-old and 8-9-year-old children

Indena curcumin complex shows eye therapy potential

Recipe for Lecithin and Tumeric & Black Pepper

US Scientists Significantly More Likely to Publish Fake Research

Cholesterol—The Good-

Cholesterol Flowing 


— Food additives and hyperactive behaviour in 3-year-old and 8-9-year-old children -a randomised, double-blinded, placebo-controlled trial
Donna McCann, Angelina Barrett, Alison Cooper, Debbie Crumpler, Lindy Dalen, Kate Grimshaw, Elizabeth Kitchin, Kris Lok, Lucy Porteous, Emily Prince, Prof Edmund Sonuga-Barke, Prof John O Warner and Prof Jim Stevenson  —- A randomised, double-blinded, placebo-controlled, crossover trial to test whether intake of artificial food colour and additives (AFCA) affected childhood behaviour. —-(153) 3-year-old and (144 )8/9-year-old children were included in the study. The challenge drink contained sodium benzoate and one of two AFCA mixes (A or B) or a placebo mix. The main outcome measure was a global hyperactivity aggregate (GHA), based on aggregated z-scores of observed behaviours and ratings by teachers and parents, plus, for 8/9-year-old children, a computerised test of attention. This clinical trial is registered with Current Controlled Trials (registration number ISRCTN74481308). Analysis was per protocol. —-Conclusion—-Artificial colours or a sodium benzoate preservative (or both) in the diet result in increased hyperactivity in 3-year-old and 8/9-year-old children in the general population
. . . The present findings, in combination with the replicated evidence for the AFCA effects on the behaviour of 3-year-old children, lend strong support for the case that food additives exacerbate hyperactive behaviours (inattention, impulsivity, and overactivity) in children at least up to middle childhood. Increased hyperactivity is associated with the development of educational difficulties, especially in relation to reading, and therefore these adverse effects could affect the child’s ability to benefit from the experience of schooling. These findings show that adverse effects are not just seen in children with extreme hyperactivity (ie, ADHD), but can also be seen in the general population and across the range of severities of hyperactivity. Our results are consistent with those from previous studies and extend the findings to show significant effects in the general population. The effects are shown after a rigorous control of placebo effects and for children with the full range of levels of hyperactivity. —We have found an adverse effect of food additives on the hyperactive behaviour of 3-year-old and 8/9-year-old children. Although the use of artificial colouring in food manufacture might seem superfluous, the same cannot be said for sodium benzoate, which has an important preservative function. The implications of these results for the regulation of food additive use could be substantial.
Indena curcumin complex shows eye therapy potential
Curcumin complex may reduce relapses of recurrent anterior uveitis by over 80 percent, according to new research. Results of the study, published in Clinical Ophthalmology, showed that after adjunct supplementation with the Indena’s curcumin–phosphatidylcholine complex, Meriva, only 18 percent of recurrent anterior uveitis patients suffered relapses. “Our work showed for the first time that Meriva formulation permits us to reach active therapeutic levels in the eye at a common dosage of two tablets per day and is well tolerated,” stated the authors, led by Dr Pia Allegri, from the Ophthalmological Department of Lavagna Hospital, in Italy. “This is the first large and controlled clinical study that demonstrates the efficacy of curcumin in eye relapsing diseases like anterior uveitis. It confirms the important anti-inflammatory activity of curcumin,” said Giovanni Appendino, Indena Scientific Advisor.
Curcumin effects
Indena said that with more than 3000 pre-clinical investigations, curcumin is one of the best investigated natural products. Curcumin has been associated with anti-inflammatory responses, and has been successfully used to treat inflammatory conditions in experimental research and in clinical trials, wrote the authors. Like most dietary phenolics, curcumin shows a very poor oral absorption, however, these problems have now been largely overcome by phospholipid complexation of curcumin, Indena claims. Uveitis is inflammation of the interior of the eye. Symptoms of recurrent anterior uveitis (RAU) include pain, redness, photophobia, and reduced vision. After reviewing several studies on curcumin and on curcumin–phosphatidylcholine complex, some investigating its anti-inflammatory effect in eye diseases, the researchers set out to demonstrate the efficacy of curcumin-phosphatidylcholine complex tablets as oral treatment of RAU.
Positive results
The authors stated that continuous and protracted treatment gave the result of a good anti-inflammatory effect and prevention of relapses. The results showed that the cumin–phosphatidylcholine complex was well tolerated, and could reduce eye discomfort symptoms and signs after a few weeks of treatment in more than 80 percent of patients. The researchers reported a total of 275 relapses one year before the treatment with curcumin complex, compared with 36 relapses at the end of the 12-month post supplementation follow-up period. This was an 88 percent improvement in RAU relapse. Moreover, the researchers reported that only one patient dropped out due to gastric intolerance to curcumin, showing that the Meriva curcumin–phosphatidylcholine complex was in the majority was well tolerated
Important role
The researchers suggested the therapeutic use of curcumin, in addition to traditional therapeutic protocols, “can play an important role in the adjunctive therapy of RAU of various origins and gives a contribution to the clinical potential efficacy of this plant-derived product in medicine.” “The success of our work suggests that curcumin’s potential anti-inflammatory effect may be useful in other chronic or relapsing ocular surface diseases, such as dry eye syndrome, allergic conjunctivitis, and blepharitis,” stated the authors.
Source: Clinical Ophthalmology
Volume 2010:4, Pages 1201-1206, doi: 10.2147/OPTH.S13271
“Management of chronic anterior uveitis relapses: efficacy of oral phospholipidic curcumin treatment. Long-term follow-up”
Authors: P. Allegri, A. Mastromarino, P. Neri
Recipe for Lecithin and Tumeric & Black Pepper—take 2 -4 ounces of lecithin and add to a blender—add 1 tablespoon of tumeric and a ½ tsp of black pepper and blend—or take in a small bowl and mix well—add ons if you wish– Vitamin A -4 capsules or the equivalent of 100,000 IU ( add more if you like or less )and Cq10 4-5 capsules of 30-100 mg strength ( use whatever you have the lipid will make the A and Cq 10 more absorbable) then use ¼ tsp 2-3 times a day—the impact will increase the effect of the antioxidant to the liver –heart- eyes-the combination makes the Cq10 last longer in the body ( due to the piperine content of pepper) the cholesterol keeps flowing as it should and by utilizing the lecithin the cells in your body maintain a healthy integrity—Brain Support is increased due to this combination of increased Choline levels and the impact of reducing plaque—will have
As well anti cancer and anti viral impact as a result of the Vitamin A and the Tumeric and Pepper—has anti parasitical impact as well as hearing and intestinal fortification
US Scientists Significantly More Likely to Publish Fake Research,
ScienceDaily (Nov. 17, 2010) — US scientists are significantly more likely to publish fake research than scientists from elsewhere, finds a trawl of officially withdrawn (retracted) studies, published online in the Journal of Medical Ethics.—Fraudsters are also more likely to be “repeat offenders,” the study shows.–The study author searched the PubMed database for every scientific research paper that had been withdrawn — and therefore officially expunged from the public record — between 2000 and 2010.–A total of 788 papers had been retracted during this period. Around three quarters of these papers had been withdrawn because of a serious error (545); the rest of the retractions were attributed to fraud (data fabrication or falsification).—The highest number of retracted papers were written by US first authors (260), accounting for a third of the total. One in three of these was attributed to fraud.–The UK, India, Japan, and China each had more than 40 papers withdrawn during the decade. Asian nations, including South Korea, accounted for 30% of retractions. Of these, one in four was attributed to fraud.—The fakes were more likely to appear in leading publications with a high “impact factor.” This is a measure of how often research is cited in other peer reviewed journals.–More than half (53%) of the faked research papers had been written by a first author who was a “repeat offender.” This was the case in only one in five (18%) of the erroneous papers.-The average number of authors on all retracted papers was three, but some had 10 or more. Faked research papers were significantly more likely to have multiple authors.Each first author who was a repeat fraudster had an average of six co-authors, each of whom had had another three retractions.—The duplicity of some authors is cause for concern,” comments the author. Retraction is the strongest sanction that can be applied to published research, but currently, “[it] is a very blunt instrument used for offences both gravely serious and trivial.”—Story Source:—The above story is reprinted (with editorial adaptations by ScienceDaily staff) from materials provided by BMJ-British Medical Journal, via EurekAlert!, a service of AAAS.—Journal Reference: R Grant Steen. Retractions in the Scientific Literature: Do Authors Deliberately Commit Research Fraud? J Med Ethics, 15 November 2010 DOI: 10.1136/jme.2010.038125
Cholesterol—The Good-
ñññOptimal serum Cholesterol levels help to prevent some types of Cerebrovascular Diseases and sub-optimal Cholesterol levels are associated with an increased risk of Cerebrovascular Diseases. ñññ
 Cholesterol is an essential component of Cell Membranes
 Cholesterol fine tunes Cell Membrane fluidity under constantly fluctuating conditions of dietary Fat intake.—    Caution:  excess Cholesterol can cause Cell Membranes to become too rigid.
Cholesterol is a particularly important constituent of the Myelin Sheath that insulates Neurons.
Cholesterol manufactured for use in Cell Membranes is manufactured in response to demand from the Cell Membranes themselves.
AL-721 increases the fluidity of Cell Membranes by removing Cholesterol thereby lowering the Cholesterol:Phospholipid ratio within Cells Membranes.
 Digestive System
Cholesterol’s byproducts (Cholic Acid, Chenodeoxycholic Acid and Deoxycholic Acid) are essential components of Bile.—Cholesterol facilitates the body’s absorption of dietary Fats in the Intestine.
 Immune System
 ñññLow Cholesterol levels increase the risk of Cancerñññ
Cholesterol (after its secretion by glands in the Skin) protects the Skin against infection by Detrimental Bacteria and Detrimental Fungi.
 ñññCholesterol possesses Antioxidant properties.  ñññ
 Nervous System 
ñññOptimal levels of Cholesterol are required in order to prevent Aggressiveness (excessively low Cholesterol levels increase the incidence of Aggressiveness).  ñññCholesterol is essential to the healthy function of the Brain.- ñññCholesterol helps to prevent Depression (low Cholesterol (under 160 mg/dl) is associated with an increased risk of Depression). ñññ–Optimal levels of Cholesterol are required in order to prevent Depression (excessively low Cholesterol levels increase the incidence of Depression).  ñññ-  Cholesterol indirectly counteracts excessive Stress (due to it being an essential constituent of the Adrenal Hormones – Adrenaline, Cortisol and Cortisone – that are released by the body in response to Stress):
Caution:  excessive Stress causes the production of excessive quantities of endogenous Cholesterol.
 Cholesterol comprises 1% of human Sebum (in which it helps to protect the Skin against dehydration and accelerates the healing of Skin Tissue). ñññ
 Cholesterol Enhances the Function of these Substances
 ñññCholesterol is an essential precursor for the formation of all Steroid Hormones.  reñññ
 Steroids – Biochemical Pathway
 Cholesterol comprises 20% of High Density Lipoproteins (HDLs)-Cholesterol comprises 46% of Lipoprotein (a).–Cholesterol comprises 46% of Low Density Lipoproteins (LDLs)-Cholesterol comprises 22% of Very Low Density Lipoproteins (VLDLs)
 Cholesterol increases the number of Receptors in the Brain for Serotonin.
ñññCholesterol is an essential precursor for the endogenous production of Vitamin D (Vitamin D3 form).  ñññ
 These Substances Enhance the Function of Cholesterol
 Electromagnetic Radiation
Ultra-Violet Radiation converts the 7-Dehydrocholesterol form of Cholesterol to the Cholecalciferol (Vitamin D3) form of Vitamin D in the Skin: 
Manganese facilitates the conversion of Cholesterol into Steroid Hormones.
Steroid Biosynthetic Pathways
3b-Hydroxysteroid dehydrogenase/!5-!4-isomerase
17b-Hydroxysteroid dehydrogenase
* P450-18
Designation Name
P450scc Cholesterol side chain cleavage enzyme
P450-17a 17a-hydroxylase/17-20-lyase
P450-21 21-hydroxylase
P450-11b 11b-hydroxylase
P450-18 18-hydroxylase
P450-arom aromatase
Note that P450-17a catalyzes both reactions in the conversion
of pregnenolone to DHEA and in the conversion of
progesterone to androstenedione.

Cholesterol Flowing—

Bay Leaf — In vitro and in vivo effects of Laurus nobilis L. leaf extracts.

Kaurinovic B, Popovic M, Vlaisavljevic S.

Department of Chemistry, Faculty of Science, University of Novi Sad, Trg Dositeja Obradovica 3, 21000 Novi Sad, Serbia.


The in vitro and in vivo antioxidant activities of different extracts of laurel leaves were studied. Free radical scavenging capacity (RSC) was evaluated measuring the scavenging activity on the DPPH, NO, O(2)(.-) and OH radicals. The effects on lipid peroxidation (LP) were also evaluated. Experimental results indicate that ethyl acetate extract of leaves has exhibited the largest RSC capacity in neutralization[U1]  of DPPH, NO, O(2)(.-) and OH radicals. The same result was obtained in investigation of extracts impact on LP. The in vivo effects were evaluated on some antioxidant systems (activities of GSHPx, LPx, Px, CAT and XOD, and GSH content) in the mice liver and blood-hemolysate after treatment with the examined laurel extracts, or in combination with carbon tetrachloride (CCl(4)). On the basis of the results obtained it can be concluded that the examined extracts exhibited a certain protective effect, which is more pronounced on the liver than on blood-hemolysate parameters. The results obtained indicate toxicity of CCl(4), probably due to the radicals involved in its metabolism. Combined treatments with CCl(4) and the examined extracts showed both positive and negative synergism. Based on the experimental results, the strongest protective effect was shown by the EtOAc extract.– PMID: 20657487 [PubMed – indexed for MEDLINE]

Grapefruit lowers total serum Cholesterol levels (due to the Grapefruit Pectin content of Grapefruit). 

Oranges lower total serum Cholesterol levels (primarily due to the Pectin content of Oranges). 

Pears lower total serum Cholesterol levels (due to the Pectin content of Pears).

Strawberries lower total serum Cholesterol levels (due to the Pectin content of Strawberries).

Almonds lower total serum Cholesterol levels (due to the Oleic Acid content of Almonds). 

Pecan Nuts lower total serum Cholesterol levels (due to the Beta-Sitosterol content of Pecan Nuts).

Fats that lower or Utilize Cholesterol—

Coconut Oil lowers elevated total serum Cholesterol levels (it is speculated that this occurs from Coconut Oil stimulating the conversion of Cholesterol to Pregnenolone)

Olive Oil lowers total serum Cholesterol, by preventing it from entering the bloodstream (due to the Cycloartenol content of Olive Oil). 

Rice Bran Oil lowers total serum Cholesterol levels. 

Perilla Oil lowers elevated serum Cholesterol levels (due to the high Alpha-Linolenic Acid content of Perilla Oil). 

Processed Foods & Unprocessed Foods

ñññLecithin (10,500 mg per day) lowers elevated serum Cholesterol levels (by approximately 33%).ñññ  Sunflower or Egg Lecithin Would be the Choice

Avocado lowers serum Cholesterol levels. 

Cabbage helps to lower total serum Cholesterol levels.

Carrots lower serum Cholesterol levels:  research

Consumption of 200 grams of raw Carrots lowers total serum Cholesterol levels by an average of 11%.

Celery can lower total serum Cholesterol by 7%, even at low doses (due to the 3-n-Butyl-Phthalide content of Celery). 

Garlic (and Garlic Oil) lowers total serum Cholesterol levels:  research

Aged Garlic Extract lowers total serum Cholesterol levels (by approximately 7%). 

Globe Artichoke lowers total serum Cholesterol levels (due to the Cynarin content of Globe Artichokes). 

Onions lower total serum Cholesterol levels. 

Rutabaga lowers total serum Cholesterol levels.

Sweet Potatoes lower total serum Cholesterol levels (by binding to Cholesterol).

Turnips lower total serum Cholesterol levels



Herb &Fungi (Mushroooms)

Caterpillar Fungus lowers total serum Cholesterol levels by an average of 17.5%.  Cordycep

Shiitake Mushrooms lower total serum Cholesterol levels (due to the Eritadenin content of Shiitake Mushrooms).  research

American Ginseng lowers total serum Cholesterol levels. 

Arjuna lowers total serum Cholesterol levels. 

Artichoke Leaf lowers total serum Cholesterol levels. 

Black Cohosh lowers serum Cholesterol levels.

Carob lowers total serum Cholesterol levels by up to 15%. 

Chillis lower total serum Cholesterol levels (due to the Capsaicin and Dihydrocapsaicin content of Chillis). 

Ginger lowers total serum Cholesterol levels. 

Ginsengs lower total serum Cholesterol levels.

Green Tea lowers total serum Cholesterol levels. 

Guggulipid (extract) lowers elevated serum Cholesterol levels (by stimulating the function of the Thyroid, inhibiting the endogenous production of Cholesterol and facilitating the excretion of Cholesterol).  This regulates T3 –T4 Conversions

Hawthorn (berries) lower total serum Cholesterol levels. 

Holy Basil lowers total serum Cholesterol levels. 

Indian Gooseberry lowers total serum Cholesterol levels. 

Jiaogulan lowers total serum Cholesterol levels.

Milk Thistle lowers elevated total serum Cholesterol levels (due to the Silymarin content of Milk Thistle). 

Skullcap inhibits increases in serum Cholesterol levels.

Turmeric lowers total serum Cholesterol levels (due to the Curcumin content of Turmeric).

Yarrow lowers total serum Cholesterol levels

Rosemary—Sage –Thyme-Bay Leaf as well work with cholesterol as to not to allow it to break down and periodize ( get broken and become sticky causing arterial stress )

AS you can see The need for Cholesterol Is A NECESSITY—and should be treated as such –as you can see based on the research without it cancer increases



 [U1]Here they are showing that Bay Leaf had the Highest antioxidant capcity toward fat break down –it appears to be neutralizing this