Fast-Acting Carbs May Hasten Vision Loss Over Time
Grape Seed Extract Bollixes Norovirus
- New Form of Brain Plasticity- How Social Isolation Disrupts Myelin Production
- Limiting Carbs to Dinner-Time Increases Satiety, Reduces Risk for Diabetes and Cardiovascular Disease
Age-Related Macular Degeneration Treatment Works Even With Other Eye Problem
ScienceDaily (Nov. 11, 2012) — Animals that are socially isolated for prolonged periods make less myelin in the region of the brain responsible for complex emotional and cognitive behavior, researchers at the University at Buffalo and Mt. Sinai School of Medicine report in Nature Neuroscience online.—The research sheds new light on brain plasticity, the brain’s ability to adapt to environmental changes. It reveals that neurons aren’t the only brain structures that undergo changes in response to an individual’s environment and experience, according to one of the paper’s lead authors, Karen Dietz, PhD, research scientist in the Department of Pharmacology and Toxicology in the UB School of Medicine and Biomedical Sciences.—Dietz did the work while a postdoctoral researcher at Mt. Sinai School of Medicine; Jia Liu, PhD, a Mt. Sinai postdoctoral researcher, is the other lead author.–The paper notes that changes in the brain’s white matter, or myelin, have been seen before in psychiatric disorders, and demyelinating disorders have also had an association with depression. Recently, myelin changes were also seen in very young animals or adolescents responding to environmental changes.–“This research reveals for the first time a role for myelin in adult psychiatric disorders,” Dietz says. “It demonstrates that plasticity in the brain is not restricted to neurons, but actively occurs in glial cells, such as the oligodendrocytes, which produce myelin.”Myelin is the crucial fatty material that wraps the axons of neurons and allows them to signal effectively. Normal nerve function is lost in demyelinating disorders, such as MS and the rare, fatal, childhood disease, Krabbe’s disease. –This paper reveals that the stress of social isolation disrupts the sequence in which the myelin-making cells, the oligodendrocytes, are formed.–In the experiment, adult mice, normally social animals, were isolated for eight weeks to induce a depressive-like state. They were then introduced to a “novel” mouse, one they hadn’t seen before; while mice are normally highly motivated to be social, those who had been socially isolated did not show any interest in interacting with the new mouse, a model of social avoidance and withdrawal. –Brain tissue analysis of the socially isolated animals revealed significantly lower than normal levels of gene transcription for oligodendrocyte cells in the prefrontal cortex, a brain region responsible for emotional and cognitive behavior.—“This research provides the first explanation of the mechanism behind how this brain plasticity occurs,” says Dietz, “showing how this change in the level of social interaction of the adult animal resulted in changes in oligodendrocytes.”—The key change was that cellular nuclei in the prefrontal cortex contained less heterochromatin, a tightly packed form of DNA material, which is unavailable for gene expression.—“This process of DNA compaction is what signifies that the oligodendrocytes have matured, allowing them to produce normal amounts of myelin,” says Dietz. “We have observed in socially isolated animals that there isn’t as much compaction, and the oligodendrocytes look more immature. As adults age, normally, you would see more compaction, but when social isolation interferes, there’s less compaction and therefore, less myelin being made.”
She adds, however, that the research also showed that myelin production went back to normal after a period of social integration, suggesting that environmental intervention was sufficient to reverse the negative consequences of adult social isolation. —The new paper, together with a report published earlier this year by another group showing myelin changes triggered by social isolation early in life will broaden investigations into brain plasticity, says David Dietz, PhD, one of the paper’s co-authors, an assistant professor of pharmacology and toxicology at UB.—In addition, adds Karen Dietz, the work has implications for future questions regarding MS and other myelin disorders. “This research suggests that maybe recovery from an MS episode might be enhanced by social interaction,” she says. “This opens another avenue of investigation of how mood and myelin disorders may interact with one another.” Major funding for the research came from the National Institutes of Health.–Story Source—The above story is reprinted from materials provided by University at Buffalo, via Newswise. —Journal Reference–Jia Liu, Karen Dietz, Jacqueline M DeLoyht, Xiomara Pedre, Dipti Kelkar, Jasbir Kaur, Vincent Vialou, Mary Kay Lobo, David M Dietz, Eric J Nestler, Jeffrey Dupree, Patrizia Casaccia. Impaired adult myelination in the prefrontal cortex of socially isolated mice. Nature Neuroscience, 2012; DOI: 10.1038/nn.3263
Things That also help to maintain the myelin sheath and rebuild it—Copper(Copper may contribute to the integrity of the Myelin Sheaths surrounding Neurons (due to its role in the synthesis of some Phospholipids). Glycerol(Glycerol is a component of Phopholipids (Phospholipids are components of all Cell Membranes and Tissues within the body: Phospholipids are especially prevalent in the Brain.–Phospholipids surround the Mitochondria, Nucleus, Nucleolus, Lysosomes and form the membranous structures of Golgi and Endoplasmic Reticulum.—-The Phospholipid component of Cell Membranes keeps water-insoluble Fatty Acids, Cholesterol, Vitamin A and Vitamin E soluble in the watery bloodstream.–Phospholipids help to determine which substances can drift (or be pulled into) Cells from outside and which substances from within Cells will drift (or be pushed) out.—Phospholipids are involved in the regulation of the body’s Water Balance.–Phospholipids hold endogenous Proteins in place in Cell Membranes to fulfil their structural, enzymatic and transport functions. Octacosanol (Octacosanol, an active ingredient found in wheat germ oil, has been reported to be of benefit to some Parkinson’s patients. It attracted scientific interest when it was found to enhance the swimming performance of guinea pigs during wheat germ studies. Octacosanol was also reported that octacosanol boosted androgen production when administered to chicks. Another study suggested that octacosanol improved oxygen utilization in rats that experienced a more rapid reproduction) may regenerate and repair Myelin Sheaths. Cholesterol is an essential component of Myelin Sheaths.
Grape Seed Extract Bollixes Norovirus
ScienceDaily (Nov. 8, 2012) — Norovirus causes more than half of all food-born illnesses in the United States, and is the second greatest source of reported food borne illness outbreaks in the European Union. A recent study found that grape seed extract could reduce the infectivity of Norovirus surrogates (Norovirus surrogates are viruses that share pathological and/or biological features with human norovirus). Now, Dan Li of Ghent University, Ghent, Belgium and collaborators have shown that grape seed extract does so by denaturing the capsid protein, which is the coat of the virus, thereby disabling the virus.–The research is published in the November 2012 issue of Applied and Environmental Microbiology.—-In the study, the researchers observed that under treatment with grape seed extract, at low doses, the spherically-shaped murine (mouse) norovirus-1 coat proteins clumped, and showed “obvious deformation and inflation,” according to the report. At higher doses, the researchers saw no coat proteins, only protein debris. “This provides evidence that [grape seed extract] could effectively damage the [norovirus] capsid protein, which could reduce viral binding ability and infectivity accordingly,” according to the report.—-The researchers used surrogate viruses because there are no suitable animal models of norovirus, and human norovirus has been impossible to propagate in cell cultures. The surrogate virus, murine norovirus-1, can be grown in cell culture, and belongs to the same genus as human norovirus, and has a very similar genome structure, and morphology. Nonetheless, the researchers were able to measure the specific binding strength of human norovirus by two different methods, finding that it declined precipitously under the influence of grape seed extract, providing further support to their results.—Norovirus is transmitted mainly fecal-orally, and infected food handlers, contaminated water, and surfaces can be identified as important sources of transmission, “which could further contaminate ready-to-eat foods, drinking water, shellfish, and fresh produce,” says Li. A mere 10-100 virus particles are sufficient to transmit the disease.—Story Source-The above story is reprinted from materials provided by American Society for Microbiology. —Journal Reference-D. Li, L. Baert, D. Zhang, M. Xia, W. Zhong, E. Van Coillie, X. Jiang, M. Uyttendaele. Effect of Grape Seed Extract on Human Norovirus GII.4 and Murine Norovirus 1 in Viral Suspensions, on Stainless Steel Discs, and in Lettuce Wash Water. Applied and Environmental Microbiology, 2012; 78 (21): 7572 DOI: 10.1128/AEM.01987-12
Due to the OPC content of the grape seed it has a high value of use as well for other things from renewing antioxidant recharge to Vitamin E to a synergistic effect with vitamin C –this will cause a retarding of aging—it has been known to protect the RNA as well as protect against cancer and liver poisoning from Tylenol—it has also been shown to protect against Grape seed extract has also been shown to protect against bacterial infections, such as Staphylococcus aureus. Some studies — mostly in animals — support these uses—
Fast-Acting Carbs May Hasten Vision Loss Over Time
A study this year confirms earlier findings linking high consumption of fast-acting carbs over time with age-related macular degeneration (AMD).
ScienceDaily (Dec. 1, 2007) — Consuming higher-than-average amounts of carbohydrates that cause blood sugar levels to spike and fall rapidly could be a risk factor for central vision loss with aging. —The study was led by Chung-Jung Chiu with Allen Taylor, both at the Jean Mayer USDA Human Nutrition Research Center on Aging (HNRCA) in Boston, Mass. Taylor is director of the Laboratory for Nutrition and Vision Research at the HNRCA. –The researchers analyzed dietary intake and other data from more than 4,000 men and women aged 55 to 80 participating in the Age-Related Eye Disease Study, or AREDS.–Diets high in carbohydrates that are quickly digested and absorbed, resulting in a rapid rise in blood sugar levels, are considered high-glycemic-index diets. Examples of such “fast carb” foods are white bread, rice, potatoes and pasta, and also sugars and corn syrups. Carbohydrates leading to a more gradual rise and fall in blood sugar levels comprise low-glycemic-index diets. Such “slow carb” foods include whole-grain versions of bread, rice and pasta.[U1] Central vision loss is one of the first signs of age-related macular degeneration (AMD), a disease that is one of the leading causes of blindness among the elderly. —Consuming a diet high in fast carbs is also suspected of being involved in the vision loss that sometimes occurs in people with diabetes. The researchers theorize that the type of damage to eye tissue produced by fast carbs could be similar in both AMD and diabetic eye disease. —At this time, there is no effective cure for AMD, so finding modifiable risk factors is important. While it’s too soon to recommend dietary slow carbs as a preventive strategy for AMD, replacing fast carbs with Antioxidant enriched veges and fruits and the use of sprouts and juices made at home may soon prove to be not only a early dietary intervention to slow its progression- but potentially a cure –=Scientists supported by the Agricultural Research Service (ARS) and grants reported the findings this year in the American Journal of Clinical Nutrition. -Story Source—The above story is reprinted from materials provided by US Department of Agriculture.
Limiting Carbs to Dinner-Time Increases Satiety, Reduces Risk for Diabetes and Cardiovascular Disease, Research Finds
An experimental diet with carbohydrates eaten mostly at dinner could benefit people suffering from severe and morbid obesity.—ScienceDaily (Nov. 11, 2012) — An experimental diet with carbohydrates eaten mostly at dinner could benefit people suffering from severe and morbid obesity, according to new research at the Hebrew University of Jerusalem.–The diet influences secretion patterns of hormones responsible for hunger and satiety, as well as hormones associated with metabolic syndrome. In this way the diet can help dieters persist over the long run, and reduce risk factors for diabetes and cardiovascular disease.—The research was carried out by research student Sigal Sofer under the auspices of Prof. (Emeritus) Zecharia Madar, at the Institute of Biochemistry, Food Science and Nutrition at the Hebrew University’s Robert H. Smith Faculty of Agriculture, Food and Environment. (Prof. Madar is now Chief Scientist at Israel’s Ministry of Education.)–Sofer randomly assigned 78 police officers to either the experimental diet (carbohydrates at dinner) or a control weight loss diet (carbohydrates throughout the day). 63 subjects finished the six-month program.–The researchers examined the experimental diet’s effect on the secretion of three hormones: leptin, considered to be the satiety hormone, whose level in the blood is usually low during the day and high during the night; ghrelin, considered the hunger hormone, whose level in the blood is usually high during the day and low during the night; and adiponectin, considered the link between obesity, insulin resistance and the metabolic syndrome, whose curve is low and flat in obese people.—“The idea came about from studies on Muslims during Ramadan, when they fast during the day and eat high-carbohydrate meals in the evening, that showed the secretion curve of leptin was changed,” explained Prof. Madar.–The researchers found that the innovative dietary manipulation led to changes in daylight hormonal profiles in favor of the dieters: the satiety hormone leptin’s secretion curve became convex during daylight hours with a nadir in the late day; the hunger hormone ghrelin’s secretion curve became concave, peaking only in the evening hours; and the curve of adiponectin, considered the link between obesity, insulin resistance and the metabolic syndrome, was elevated. At the same time this dietary pattern led to lower hunger scores, and better anthropometric (weight, abdominal circumference and body fat), biochemical (blood sugar, blood lipids) and inflammatory outcomes compared to the control group[U2] .—The findings suggest there is an advantage in concentrating carbohydrate intake in the evening, especially for people at risk of developing diabetes or cardiovascular disease due to obesity. “The findings lay the basis for a more appropriate dietary alternative for those people who have difficulty persisting in diets over time,” said Prof. Madar. “The next step is to understand the mechanisms that led to the results obtained.”—The study was published in two continuous papers: “Greater weight loss and hormonal changes after 6 months diet with carbohydrates eaten mostly at dinner” (published in Obesity) and “Changes in daily leptin, ghrelin and adiponectin profiles following a diet with carbohydrates eaten at dinner in obese subjects” (published in Nutrition, Metabolism & Cardiovascular Diseases).—Sources of support for the study include Meuhedet Medical Services, Israel; the Israeli Police Force; the Kaplan Medical Center in Rehovot, Israel (for Dr. Fink); the Israel Diabetes Association; and the Israel Lung and Tuberculosis Association (for Prof. Eliraz).—Story Source–The above story is reprinted from materials provided by Hebrew University of Jerusalem. —Journal References-S. Sofer, A. Eliraz, S. Kaplan, H. Voet, G. Fink, T. Kima, Z. Madar. Changes in daily leptin, ghrelin and adiponectin profiles following a diet with carbohydrates eaten at dinner in obese subjects. Nutrition, Metabolism and Cardiovascular Diseases, 2012; DOI: 10.1016/j.numecd.2012.04.008Sigal Sofer, Abraham Eliraz, Sara Kaplan, Hillary Voet, Gershon Fink, Tzadok Kima, Zecharia Madar. Greater Weight Loss and Hormonal Changes After 6 Months Diet With Carbohydrates Eaten Mostly at Dinner. Obesity, 2011; 19 (10): 2006 DOI: 10.1038/oby.2011.48
Age-Related Macular Degeneration Treatment Works Even With Other Eye Problem
ScienceDaily (Nov. 11, 2012) — The primary treatment for wet macular degeneration, a chronic eye condition that causes vision loss, is effective even if patients have macular traction problems, a Mayo Clinic study shows.–The findings will be presented today at the annual meeting of the American Academy of Ophthalmology in Chicago.–Due to the aging population, an increasing number of patients are being treated for age-related macular degeneration (AMD), an eye condition in which abnormal blood vessels develop and leak into the eye. When patients develop wet AMD, they receive injections of anti-vascular endothelial growth factor medication (VEGF). VEGF prompts growth of new blood vessels in the body. In the case of AMD, however, such new growth is unwanted and may cause bleeding in the retina.—It has not been clear whether this treatment would also serve patients experiencing other symptoms, such as vitreomacular interface disease (VMID), in which there is traction or contact between the retina and the vitreous matter in the eye. Mayo researchers retrospectively studied 178 patients, of whom 18 percent had VMID over an average of 2.5 years.–Findings showed that while eyes with some kind of macular traction required more injections, they still showed improvement (best corrected visual acuity) to similar eyes without VMID.–“This finding is significant,” says senior author Sophie J. Bakri, M.D., “because it showed that patients with VMID are not necessarily treatment resistant for AMD.” She also says it may help physicians not give up on treating such patients, and understand the need for more doses of medication for those with VMID. Researchers say more study is needed, including a prospective clinical trial.–Co-authors include Amy Green-Simms, M.D., Blake Fechtel and Zubin Agarwal, M.P.H., all of Mayo Clinic. The research was funded in part by Research to Prevent Blindness.–Story Source–The above story is reprinted from materials provided by Mayo Clinic.
Special Note–In my videos I show 3 remedies that someone has used all at once—the controversial remedy—the pain killing remedy and the ginger onion grapefruit remedy-after 30 years of being blind in one eye he got restored where he was blind–These 3 remedies were taken at one time several times a day—this maybe another option for you to try