Tony Pantalleresco Radio Show notes – December 6th 2014

Tony Pantallaresco

Welcome to Tony Pantalleresco Radio Show notes – December 6th 2014

In this weeks show, Tony talks about the following topics:

Glyphosate-Endocrine Disrupting
Stick out your tongue- Tongue appearance and illness
Antiproliferative activity and induction of apoptotic by ethanolic extract of Alpinia galanga rhizhome in human breast carcinoma cell line
A high whey protein–, leucine-, and vitamin D–enriched supplement preserves muscle mass during intentional weight loss
Cottage Cheese Making

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Vitamin D may save 40,000 Canadian lives per year

Vitamin D may save 40,000 Canadian lives per year

By Stephen Daniells, 02-Apr-2010

Related topics: Formulation

Inadequate levels of vitamin D may be causing about 37,000 premature deaths in Canada and costing the country billions of dollars, according to a new review.

Writing in Molecular Nutrition & Food Research, researchers led by William Grant from the Sunlight, Nutrition, and Health Research Center (SUNARC) in San Francisco report that the economic burden was also decrease if vitamin D levels were improved, and would save about $14.4 billion.

“The results of this study strongly suggest that the personal and economic burden of disease in Canada could be significantly reduced if the mean serum 25(OH)D level was increased from its current level of 67 nmol/L to the optimal level of 105nmol/L,” wrote the researchers.

“These results should increase interest by individuals, researchers, organizations, and agencies in Canada in assessing the health benefits of higher vitamin D production and intake and modifying practices and recommendations accordingly,” they added.

The study was funded by the Vitamin D Society (Canada), the UV Foundation (US), the Sunlight Research Forum (The Netherlands), Bio-Tech-Pharmacal (US), Dairy Farmers, Yoplait, and IADSA.

The lowdown on D

Vitamin D deficiency in adults is reported to precipitate or exacerbate osteopenia, osteoporosis, muscle weakness, fractures, common cancers, autoimmune diseases, infectious diseases and cardiovascular diseases. There is also some evidence that the vitamin may reduce the incidence of several types of cancer and type-1 diabetes.

The science supporting the muscle function of vitamin D, as well as the vitamin’s role in immune health, is sufficiently robust to have merited a positive opinion from the European Food Safety Authority’s (EFSA) Panel on Dietetic Products, Nutrition and Allergies (NDA).

Despite such proclamations of support, many people across the world are not getting enough vitamin D. Data obtained from Statistics Canada allowed Grant and his co-workers to estimate that improved vitamin D levels would reduce the incidence of chronic disease and could reduce mortality by 16 percent, or 37,000 fewer deaths.

This would alleviate the economic burden by about 7 percent, according to data from Health Canada, or $14.4 billion “less the cost of the program”, they said.

The times they may be a-changing

The influential Institute of Medicine (IOM) is conducting a review of the available vitamin D science and is due to deliver its findings this summer. Many expect the IOM to recommend RDIs much above the current levels of 400IU. Oprah has been telling her viewers the RDI should be 2000IU or more.

The IOM may also revise upper safe levels (USLs) with some saying 10,000IU per day reflects the scientific literature – this would be a great boon to supplement manufacturers seeking to meet demand for high-dose products.

Source: Molecular Nutrition & Food Research
 Published online ahead of print, doi: 10.1002/mnfr.200900420
“An estimate of the economic burden and premature deaths due to vitamin D deficiency in Canada”
Authors: W.B. Grant, G.K. Schwalfenberg, S.J. Genuis, S.J. Whiting

Supplements and sunlight give optimal protection from breast cancer: Study

Supplements and sunlight give optimal protection from breast cancer: Study

Post a commentBy Stephen Daniells, 16-Dec-2010

Related topics: Research, Vitamins & premixes, Cancer risk reduction

Some sun exposure and vitamin D supplements may be the most effective means of reducing the risk of breast cancer, suggest findings from a French study.

 

Numerous studies have linked vitamin D levels to a reduction in the risk of certain cancers, including breast cancer, but much debate has focused on the means to boost vitamin D levels – supplements or sunlight.

According to new findings published in Cancer Epidemiology, Biomarkers & Prevention, a combination may be the best approach. Data collected over a decade of study from 67,721 women indicated that postmenopausal women living in sunny climes combined with high dietary or supplemental intakes of vitamin D were at a significantly reduced risk of breast cancer compared to women with high sun exposure and low intakes of the vitamin.

On the other hand, no associations were observed for dietary and supplemental intakes of vitamin D alone, report researchers led by Pierre Engel from Inserm (Institut National de la Santé et de la Recherche Médicale).

“Although, our results do not support a linear dose-response relationship of both UVR dose and dietary vitamin D on BC risk, our findings suggest that a threshold of vitamin D exposure is required to prevent BC; this minimal amount is likely to vary with individual ability to metabolize or synthesize vitamin D from both sources,” they said.

D and the big C

The link between vitamin D intake and protection from cancer dates from the 1940s when Frank Apperly demonstrated a link between latitude and deaths from cancer, and suggested that sunlight gave “a relative cancer immunity”.

Since then there have been numerous studies suggesting associations between vitamin D and lower risks of certain cancers.

Vitamin D refers to two biologically inactive precursors – cholecalciferol (D3) and ergocalciferol (D2).

Both D3 and D2 precursors are hydroxylated in the liver and kidneys to form 25- hydroxyvitamin D (25(OH)D), the non-active ‘storage’ form, and 1,25-dihydroxyvitamin D (1,25(OH)2D), the biologically active form that is tightly controlled by the body.

There is growing evidence that 1,25(OH)2D has anticancer effects, but the discovery that non-kidney cells can also hydroxylate 25(OH)D had profound implications, implying that higher 25(OH)D levels could protect against cancer in the local sites.

The association between vitamin D and breast cancer is still ambiguous, however, according to results of a recent meta-analysis published in the European Journal of Cancer (doi: 10.1016/j.ejca.2010.03.037).

New data

According to findings of Dr Engel and his team, such ambiguity may be related to a combination of dietary, supplemental and sunlight exposure as the source of raising vitamin D levels.

The French researchers documented 2,871 cases of breast cancer over the 10 years of their study. While no relationship was observed between dietary and supplemental intakes of the sunshine vitamin, the risk of breast cancer for women residing in regions with the highest average daily UV exposure (living below a latitude of 46°N) combined with high dietary vitamin D intakes was 32 percent lower, while the risk for high UV exposure and high supplemental intakes was reduced by 45 percent.

“Considering that, in France, mean vitamin D dietary intake is low, and 25(OH) vitamin D serum concentrations are mostly below the 30 ng/mL recommended threshold, our results suggest that an increase in overall vitamin D intake should be encouraged by food and health agencies, possibly through fortification of foods,” concluded Dr Engel and his co-workers.

Jury–in or out?

The recent meta-analysis, which reviewed and summarised ten trials investigating the association between serum vitamin D (measured as 25(OH)D levels) and the risk of breast cancer, concluded that the data to date “show ambiguous evidence”.

“Data is still sparse and in depth analyses … especially measuring repeatedly 25(OH)D at different time points before diagnosis, are highly desirable to enable more precise estimates and a better understanding of the role of vitamin D in breast cancer development and prevention,” concluded the authors of the meta-analysis.

Source: Cancer Epidemiology, Biomarkers & Prevention
Published online ahead of print, doi:10.1158/1055-9965.EPI-10-1039
“Joint effects of dietary vitamin D and sun exposure on breast cancer risk: results from the French E3N cohort”
Authors: P. Engel, G. Fagherazzi, S. Mesrine, M-C. Boutron-Ruault, F. Clavel-Chapelon

Low vitamin D status associated with cognitive decline: Study

Low vitamin D status associated with cognitive decline: Study

By Nathan Gray, 02-Dec-2010

Inadequate dietary intake of vitamin D is associated with higher levels of cognitive impairment; however it remains unclear if the link is causal, according to a new study.

The study, published in Neurology, suggests that a weekly intake of less than 35 micrograms of vitamin D is associated with a greater incidence of cognitive impairment. However the researchers noted that the association could be causal in either direction, stating it is possible that low vitamin D is a result of, rather than the cause of cognitive impairment.“The main finding of this population based study …was that the weekly dietary intake of vitamin D was significantly associated with the global cognitive performance in both linear and logistic regression models, even while considering the effects of all potential confounders,” said the researchers, led by Dr Cédric Annweiler from Angers University Hospital, France.
 
           D and cognitive decline Cognitive performance declines naturally as we age, but it has been suggested that vitamin D status could impact on cognitive function among older adults.It is suggested that vitamin D binds to neuronal receptors in the brain, and develops an anti-neurodegenerative action through, anti-inflammatory and antioxidative. Many people have therefore recommended that maintaining an adequate vitamin D status is essential to avoid vitamin D deficiency– induced cognitive decline.Data from David Llewellyn and colleagues at the University of Exeter, England, indicated that insufficient levels of vitamin D may accelerate cognitive decline .
       The scientists analyzed vitamin D levels from blood samples of 858 adults and found that severe vitamin D deficiency was associated with a 60 percent increase in the risk of substantial cognitive decline.Annweiler and colleagues said the benefits of vitamin D intake in treating or preventing cognitive impairment remain unknown, adding that, to date no randomized controlled trials have explored the benefits of vitamin D supplementation to treat or prevent cognitive impairment.But, before conducting such a trial, they said it would be of benefit to determine whether dietary, non-supplemented, intake of vitamin D could be associated with cognitive performance in older adults.“We had the opportunity to examine the association between dietary intakes of vitamin D and global cognitive performance in a large representative community survey of older women,” said the researchers.
     Study detailsA total of 5,596 women, not taking vitamin D supplements were divided into 2 groups according to their baseline weekly staus: either inadequate (less than 35 micrograms per week) or recommended (more than 35 micrograms per week).Compared to women with recommended weekly vitamin D dietary intakes, women with inadequate intakes were reported to have lower scores on the SPMSQ mental state questionnaire.The researchers observed that inadequate intakes were more often associated with cognitive impairment, as defined by an SPMSQ score of less than 8.“We found an association between weekly vitamin D dietary intake and SPMSQ score. Inadequate weekly vitamin D dietary intakes were also associated with cognitive impairment,” wrote the researchers.
         CausationExactly how low dietary intakes of vitamin D and decreased cognitive performance are associated remains unclear. Annweiler and co workers noted that it is yet to be clarified whether the of association is causal, and if so, in what direction the causation may be.They stated that it remains a possibility that low vitamin D status may be a result of poor diet, due to cognitive decline. But, emphasized that vitamin D insufficiency has been suggested as a contributing factor to hypertension, which itself is a major risk factor in the development of cerebrovascular diseases and cognitive decline.Annweiler and colleagues added that nutrients are not consumed in isolation, “but rather as components of an overall diet, which is precisely considered as a modifiable risk factor for cognitive decline.”Moreover, they said that as a component of diet, low vitamin D intake may be a surrogate measure for other nutritional abnormalities, which in turn may lead to cognitive decline.Source: Neurology
Volume 74, Issue 1, Pages 27 – 32, doi: 10.1212/WNL.0b013e3181fd6352
“Association of vitamin D deficiency with cognitive impairment in older women: Cross-sectional study”
Authors: C. Annweiler, A.M. Schott, G. Allali, S.A. Bridenbaugh, R.W. Kressig, P. Allain, F. R. Herrmann, O. Beauchet